A doctor may recommend that a person try Crohn’s infusions of medications called biologics as a treatment for Crohn’s disease. Ideally, these Crohn’s infusions can help keep the condition in remission.
People can receive biologics via injection or intravenously. While they may reduce symptoms in some individuals, they also have potential side effects.
In this article, learn about the types of Crohn’s infusions, as well as what to expect from this type of treatment.
Biologics are medications that occur naturally. They are antibodies or immune compounds designed to target proteins in the body that may contribute to inflammation.
These medications can be beneficial for treating Crohn’s disease because they target specific parts of the body. Other common medicines for Crohn’s disease, such as corticosteroids, affect the whole body.
Doctors categorize these medications based on specific proteins they target. Not all biologics are available by infusion.
Examples of these medication types include:
Doctors do not usually prescribe biologics as an initial treatment for Crohn’s disease, but they may recommend them if other treatments are not working.
A doctor will instruct a person on how to prepare for a Crohn’s infusions. The procedure usually takes place in an outpatient treatment center or hospital.
However, some people may opt for receiving infusions at home, which is when a nurse comes to a person’s home to give them the medication.
As there may be a risk of an allergic reaction, a doctor will usually recommend that a person has the first few infusions at a hospital or outpatient center.
A doctor will send a prescription to the infusion center with details about the type, dose, and length of the infusion.
A person may need to avoid eating or drinking before the procedure, but this is not always the case.
Since Crohn’s infusions can take an hour or more, most centers recommend bringing reading materials or other items to help a person pass the time.
While the procedure may vary slightly, people can usually expect the following when they have a Crohn’s infusion:
A person will not usually experience immediate positive effects after having a Crohn’s infusions. It may take several weeks for an individual to notice their symptoms improving.
The length of time an infusion takes, and the frequency that a person must receive them, varies between different medications.
For example, the procedure for Remicade infusions lasts 2 to 4 hours. Doctors usually recommend receiving them every 2 weeks for 6 weeks. After that time, a person may go for infusions about every 6 to 8 weeks.
By comparison, the procedure for Entyvio infusions lasts for 30 minutes, and a person will receive further infusions after 2 weeks, 6 weeks, and then every 8 weeks after that.
Crohn’s infusions can cause a range of side effects. Many of the effects are specific to the particular medication.
When receiving any medication intravenously, it is possible to have an allergic reaction or local reaction at the IV site.
For this reason, people should always ensure they are up-to-date with their immunizations before receiving infusions.
Other risks associated with Crohn’s infusions and biologics include:
- altered liver functioning
- arthritis or joint pain
- a slightly increased cancer risk, including lymphoma, solid malignancy, and skin cancers
- a lupus-like reaction, which includes muscle aches, joint pain, a rash, and fever
A person should always discuss the risks specific to certain medication types. For example, receiving the Tysabri infusion increases the risks for a condition called progressive multifocal leukoencephalopathy (PML).
This condition occurs in people who have the John Cunningham virus, which does not usually cause any symptoms. As a result, doctors will test people for this virus before beginning Tysabri infusions.